Ontology highlight
ABSTRACT:
SUBMITTER: Saeedi BJ
PROVIDER: S-EPMC3797245 | biostudies-literature | 2013 Nov-Dec
REPOSITORIES: biostudies-literature
Saeedi Bejan J BJ Geiss Brian J BJ
Wiley interdisciplinary reviews. RNA 20130808 6
RNA viruses, such as flaviviruses, are able to efficiently replicate and cap their RNA genomes in vertebrate and invertebrate cells. Flaviviruses use several specialized proteins to first make an uncapped negative strand copy of the viral genome that is used as a template for the synthesis of large numbers of capped genomic RNAs. Despite using relatively simple mechanisms to replicate their RNA genomes, there are significant gaps in our understanding of how flaviviruses switch between negative a ...[more]