Ontology highlight
ABSTRACT:
SUBMITTER: Tsanev R
PROVIDER: S-EPMC3798401 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20131017 10
The transcription factor Gli3 is acting mainly as a transcriptional repressor in the Sonic hedgehog signal transduction pathway. Gli3 contains a repressor domain in its N-terminus from residue G106 to E236. In this study we have characterized the intracellular structure of the Gli3 repressor domain using a combined bioinformatics and experimental approach. According to our findings the Gli3 repressor domain while being intrinsically disordered contains predicted anchor sites for partner interact ...[more]