Ontology highlight
ABSTRACT:
SUBMITTER: Kaempfer R
PROVIDER: S-EPMC3798871 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Kaempfer Raymond R Arad Gila G Levy Revital R Hillman Dalia D Nasie Iris I Rotfogel Ziv Z
Toxins 20130909 9
Every adaptive immune response requires costimulation through the B7/CD28 axis, with CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and streptococcal superantigen toxins hyperstimulate the T-cell-mediated immune response by orders of magnitude, inducing a lethal cytokine storm. We show that to elicit an inflammatory cytokine storm and lethality, superantigens must bind directly to CD28. Blocking access of the superantigen to its CD28 receptor with peptides mimick ...[more]