Ontology highlight
ABSTRACT:
SUBMITTER: Hirabayashi S
PROVIDER: S-EPMC3800019 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Hirabayashi Susumu S Baranski Thomas J TJ Cagan Ross L RL
Cell 20130801 3
The risk of specific cancers increases in patients with metabolic dysfunction, including obesity and diabetes. Here, we use Drosophila as a model to explore the effects of diet on tumor progression. Feeding Drosophila a diet high in carbohydrates was previously demonstrated to direct metabolic dysfunction, including hyperglycemia, hyperinsulinemia, and insulin resistance. We demonstrate that high dietary sugar also converts Ras/Src-transformed tissue from localized growths to aggressive tumors w ...[more]