Efficient simulation of epistatic interactions in case-parent trios.
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ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC3800020 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Efficient simulation of epistatic interactions in case-parent trios.
Li Qing Q Schwender Holger H Louis Thomas A TA Fallin M Daniele MD Ruczinski Ingo I
Human heredity 20130327 1
Statistical approaches to evaluate interactions between single nucleotide polymorphisms (SNPs) and SNP-environment interactions are of great importance in genetic association studies, as susceptibility to complex disease might be related to the interaction of multiple SNPs and/or environmental factors. With these methods under active development, algorithms to simulate genomic data sets are needed to ensure proper type I error control of newly proposed methods and to compare power with existing ...[more]
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