Ontology highlight
ABSTRACT:
SUBMITTER: Xiao Y
PROVIDER: S-EPMC5340569 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Xiao Yanzi Y Taub Margaret A MA Ruczinski Ingo I Begum Ferdouse F Hetmanski Jacqueline B JB Schwender Holger H Leslie Elizabeth J EJ Koboldt Daniel C DC Murray Jeffrey C JC Marazita Mary L ML Beaty Terri H TH
Genetic epidemiology 20161226 3
Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is the most common craniofacial birth defect in humans, affecting 1 in 700 live births. This malformation has a complex etiology where multiple genes and several environmental factors influence risk. At least a dozen different genes have been confirmed to be associated with risk of NSCL/P in previous studies. However, all the known genetic risk factors cannot fully explain the observed heritability of NSCL/P, and several authors have s ...[more]