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One-pot anti-Markovnikov hydroamination of unactivated alkenes by hydrozirconation and amination.

ABSTRACT: A one-pot anti-Markovnikov hydroamination of alkenes is reported. The synthesis of primary and secondary amines from unactivated olefins was accomplished in the presence of a variety of functional groups. Hydrozirconation, followed by amination with nitrogen electrophiles, provides exclusive anti-Markovnikov selectivity. Most products are isolated in high yields without the use of column chromatography.

SUBMITTER: Strom AE 

PROVIDER: S-EPMC3800136 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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One-pot anti-Markovnikov hydroamination of unactivated alkenes by hydrozirconation and amination.

Strom Alexandra E AE   Hartwig John F JF  

The Journal of organic chemistry 20130827 17

A one-pot anti-Markovnikov hydroamination of alkenes is reported. The synthesis of primary and secondary amines from unactivated olefins was accomplished in the presence of a variety of functional groups. Hydrozirconation, followed by amination with nitrogen electrophiles, provides exclusive anti-Markovnikov selectivity. Most products are isolated in high yields without the use of column chromatography. ...[more]

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