Ontology highlight
ABSTRACT:
SUBMITTER: Grimson A
PROVIDER: S-EPMC3800283 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20070701 1
Mammalian microRNAs (miRNAs) pair to 3'UTRs of mRNAs to direct their posttranscriptional repression. Important for target recognition are approximately 7 nt sites that match the seed region of the miRNA. However, these seed matches are not always sufficient for repression, indicating that other characteristics help specify targeting. By combining computational and experimental approaches, we uncovered five general features of site context that boost site efficacy: AU-rich nucleotide composition ...[more]