Ontology highlight
ABSTRACT:
SUBMITTER: Shin C
PROVIDER: S-EPMC2942757 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Molecular cell 20100601 6
Most metazoan microRNA (miRNA) target sites have perfect pairing to the seed region, located near the miRNA 5' end. Although pairing to the 3' region sometimes supplements seed matches or compensates for mismatches, pairing to the central region has been known to function only at rare sites that impart Argonaute-catalyzed mRNA cleavage. Here, we present "centered sites," a class of miRNA target sites that lack both perfect seed pairing and 3'-compensatory pairing and instead have 11-12 contiguou ...[more]