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Construction of a spirooxindole amide library through nitrile hydrozirconation-acylation-cyclization cascade.

ABSTRACT: A library of spirooxindoles containing varied elements of structural and stereochemical diversity has been constructed via a three step, one pot nitrile hydrozirconation-acylation-cyclization reaction sequence from common acyclic indole intermediates. The resulting library was evaluated for novelty through comparison with MLSMR and Maybridge compound collections.

SUBMITTER: LaPorte MG

PROVIDER: S-EPMC3800499 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Construction of a spirooxindole amide library through nitrile hydrozirconation-acylation-cyclization cascade.

LaPorte Matthew G MG Tsegay Sammi S Hong Ki Bum KB Lu Chunliang C Fang Cheng C Wang Lirong L Xie Xiang-Qun XQ Floreancig Paul E PE

ACS combinatorial science 20130626 7

A library of spirooxindoles containing varied elements of structural and stereochemical diversity has been constructed via a three step, one pot nitrile hydrozirconation-acylation-cyclization reaction sequence from common acyclic indole intermediates. The resulting library was evaluated for novelty through comparison with MLSMR and Maybridge compound collections. ...[more]

PMID: 23731121

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