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Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade.

ABSTRACT: An enantioselective arylation-cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found among biologically active natural products.

SUBMITTER: Zhu S

PROVIDER: S-EPMC3392034 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade.

Zhu Shaolin S MacMillan David W C DW

Journal of the American Chemical Society 20120622 26

An enantioselective arylation-cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found among biologically active natural products. ...[more]

PMID: 22716914

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