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ABSTRACT:
SUBMITTER: Wiemann P
PROVIDER: S-EPMC3801025 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Wiemann Philipp P Guo Chun-Jun CJ Palmer Jonathan M JM Sekonyela Relebohile R Wang Clay C C CC Keller Nancy P NP
Proceedings of the National Academy of Sciences of the United States of America 20130930 42
The hallmark trait of fungal secondary-metabolite gene clusters is well established, consisting of contiguous enzymatic and often regulatory gene(s) devoted to the production of a metabolite of a specific chemical class. Unexpectedly, we have found a deviation from this motif in a subtelomeric region of Aspergillus fumigatus. This region, under the control of the master regulator of secondary metabolism, LaeA, contains, in its entirety, the genetic machinery for three natural products (fumitremo ...[more]