Ontology highlight
ABSTRACT:
SUBMITTER: Kopper F
PROVIDER: S-EPMC3801042 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Köpper Frederik F Bierwirth Cathrin C Schön Margarete M Kunze Meike M Elvers Ingegerd I Kranz Dominique D Saini Priyanka P Menon Manoj B MB Walter David D Sørensen Claus Storgaard CS Gaestel Matthias M Helleday Thomas T Schön Michael P MP Dobbelstein Matthias M
Proceedings of the National Academy of Sciences of the United States of America 20130930 42
DNA damage can obstruct replication forks, resulting in replicative stress. By siRNA screening, we identified kinases involved in the accumulation of phosphohistone 2AX (γH2AX) upon UV irradiation-induced replication stress. Surprisingly, the strongest reduction of phosphohistone 2AX followed knockdown of the MAP kinase-activated protein kinase 2 (MK2), a kinase currently implicated in p38 stress signaling and G2 arrest. Depletion or inhibition of MK2 also protected cells from DNA damage-induced ...[more]