Ontology highlight
ABSTRACT:
SUBMITTER: Thrall ES
PROVIDER: S-EPMC9565051 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Thrall Elizabeth S ES Piatt Sadie C SC Chang Seungwoo S Loparo Joseph J JJ
Proceedings of the National Academy of Sciences of the United States of America 20221003 41
Translesion synthesis (TLS) polymerases bypass DNA lesions that block replicative polymerases, allowing cells to tolerate DNA damage encountered during replication. It is well known that most bacterial TLS polymerases must interact with the sliding-clamp processivity factor to carry out TLS, but recent work in <i>Escherichia coli</i> has revealed that single-stranded DNA-binding protein (SSB) plays a key role in enriching the TLS polymerase Pol IV at stalled replication forks in the presence of ...[more]