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Whole genome comparison of donor and cloned dogs.

ABSTRACT: Cloning is a process that produces genetically identical organisms. However, the genomic degree of genetic resemblance in clones needs to be determined. In this report, the genomes of a cloned dog and its donor were compared. Compared with a human monozygotic twin, the genome of the cloned dog showed little difference from the genome of the nuclear donor dog in terms of single nucleotide variations, chromosomal instability, and telomere lengths. These findings suggest that cloning by somatic cell nuclear transfer produced an almost identical genome. The whole genome sequence data of donor and cloned dogs can provide a resource for further investigations on epigenetic contributions in phenotypic differences.

SUBMITTER: Kim HM

PROVIDER: S-EPMC3801109 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Whole genome comparison of donor and cloned dogs.

Kim Hak-Min HM Cho Yun Sung YS Kim Hyunmin H Jho Sungwoong S Son Bongjun B Choi Joung Yoon JY Kim Sangsoo S Lee Byeong Chun BC Bhak Jong J Jang Goo G

Scientific reports 20131021

Cloning is a process that produces genetically identical organisms. However, the genomic degree of genetic resemblance in clones needs to be determined. In this report, the genomes of a cloned dog and its donor were compared. Compared with a human monozygotic twin, the genome of the cloned dog showed little difference from the genome of the nuclear donor dog in terms of single nucleotide variations, chromosomal instability, and telomere lengths. These findings suggest that cloning by somatic cel ...[more]

PMID: 24141358

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