Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

De novo copy number variations in cloned dogs (Illumina SNP)

ABSTRACT: De novo copy number variations in cloned dogs from the same nuclear donor In this study, we aimed to identify de novo post-cloning CNV events and estimated the rate of CNV mosaicism in cloned dogs with the identical genetic background.

ORGANISM(S): Canis lupus familiaris

PROVIDER: GSE49123 | GEO | 2013/12/17

SECONDARY ACCESSION(S): PRJNA213720

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Shared Molecules

Only show the datasets with similarity scores above: 0.5

Threshold

0.5

Similar Datasets

De novo copy number variations in cloned dogs (Nimblegen)

Project description:De novo copy number variations in cloned dogs from the same nuclear donor In this study, we aimed to identify de novo post-cloning CNV events and estimated the rate of CNV mosaicism in cloned dogs with the identical genetic background.

2013-12-17 | GSE49092 | GEO

De novo copy number variations in cloned dogs (Nimblegen)

2013-12-17 | E-GEOD-49092 | biostudies-arrayexpress

De novo copy number variations in cloned dogs (Illumina SNP)

2013-12-17 | E-GEOD-49123 | biostudies-arrayexpress

Somatic Mutation Patterns in Cloned Dogs: Implications for Aging

Project description:Studies on somatic mutations in cloned animals have revealed slight genetic variances between clones and their originals but have yet to identify the precise effects of these differences within the organism. Somatic mutations contribute to aging and are implicated in tumor development and other age-related diseases. To explore this, we compared whole genome sequencing data of an original dog with cloned dogs, identifying 8,155 candidate somatic mutations. By analyzing mutational signatures and rates within relevant genes, we identified potential associations with aging. Further analysis of 239 homozygous mutations within 189 genes revealed significant enrichment of traits related to chronotype, adult body size, height, spherical equivalent or myopia, and age at first sexual intercourse, suggesting these genes play roles in both growth and aging, as indicated by changes during adolescence.

2024-06-17 | E-MTAB-13924 | biostudies-arrayexpress

Somatic Mutation Patterns in Cloned Dogs: Implications for Aging

Project description:Somatic Mutation Patterns in Cloned Dogs: Implications for Aging

| PRJEB74060 | ENA

Cloned Dog

Project description:Whole genome comparison of donor and cloned dogs

| PRJEB4691 | ENA

Project description:De novo copy number variations in cloned dogs

| PRJNA213718 | ENA

Canis lupus familiaris

Project description:De novo copy number variations in cloned dogs (Nimblegen)

| PRJNA213717 | ENA

Mapping DNA structural variation in dogs

Project description:DNA structural variation (SV) comprises a major portion of genetic diversity, but its biological impact is unclear. We propose that the genetic history and extraordinary phenotypic variation of dogs make them an ideal mammal in which to study the effects of SV on biology and disease. The hundreds of existing dog breeds were created by selection of extreme morphological and behavioral traits. And along with those traits, each breed carries increased risk for different diseases. We used array CGH to create the first map of DNA copy number variation (CNV) or SV in dogs. The extent of this variation, and some of the gene classes affected, are similar to those of mice and humans. Most canine CNVs affect genes, including disease and candidate disease genes, and are thus likely to be functional. We identified many CNVs that may be breed or breed class specific. Cluster analysis of CNV regions showed that dog breeds tend to group according to breed classes. Our combined findings suggest many CNVs are (1) in linkage disequilibrium with flanking sequence, and (2) associated with breed specific traits. We discuss how a catalog of structural variation in dogs will accelerate the identification of the genetic basis of canine traits and diseases, beginning with the use of whole genome association and candidate CNV/gene approaches. Chen WK, Swartz JD, Rush LJ, Alvarez, CE. Mapping DNA structural variation in dogs. Genome Res. 2009. 19: 500 509 PMID: 19015322 Array comparitive genomic hybridization analysis of structural variation in 9 dogs, and 1 lymphoma cell line.

2010-05-22 | E-GEOD-18317 | biostudies-arrayexpress

Mapping DNA structural variation in dogs

2009-09-30 | GSE18317 | GEO