Ontology highlight
ABSTRACT:
SUBMITTER: Wolfe MS
PROVIDER: S-EPMC3801419 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Biochimica et biophysica acta 20131201 12
Presenilin is the catalytic component of the γ-secretase complex, a membrane-embedded aspartyl protease that plays a central role in biology and in the pathogenesis of Alzheimer's disease. Upon assembly with its three protein cofactors (nicastrin, Aph-1 and Pen-2), presenilin undergoes autoproteolysis into two subunits, each of which contributes one of the catalytic aspartates to the active site. A family of presenilin homologs, including signal peptide peptidase, possess proteolytic activity wi ...[more]