Ontology highlight
ABSTRACT:
SUBMITTER: Vehlow A
PROVIDER: S-EPMC3801443 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Vehlow Anne A Soong Daniel D Vizcay-Barrena Gema G Bodo Cristian C Law Ah-Lai AL Perera Upamali U Krause Matthias M
The EMBO journal 20130927 20
The epidermal growth factor receptor (EGFR) plays an essential role during development and diseases including cancer. Lamellipodin (Lpd) is known to control lamellipodia protrusion by regulating actin filament elongation via Ena/VASP proteins. However, it is unknown whether this mechanism supports endocytosis of the EGFR. Here, we have identified a novel role for Lpd and Mena in clathrin-mediated endocytosis (CME) of the EGFR. We have discovered that endogenous Lpd is in a complex with the EGFR ...[more]