Ontology highlight
ABSTRACT:
SUBMITTER: Liu CT
PROVIDER: S-EPMC3804308 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Liu C-T CT Ng M C Y MC Rybin D D Adeyemo A A Bielinski S J SJ Boerwinkle E E Borecki I I Cade B B Chen Y D I YD Djousse L L Fornage M M Goodarzi M O MO Grant S F A SF Guo X X Harris T T Kabagambe E E Kizer J R JR Liu Y Y Lunetta K L KL Mukamal K K Nettleton J A JA Pankow J S JS Patel S R SR Ramos E E Rasmussen-Torvik L L Rich S S SS Rotimi C N CN Sarpong D D Shriner D D Sims M M Zmuda J M JM Redline S S Kao W H WH Siscovick D D Florez J C JC Rotter J I JI Dupuis J J Wilson J G JG Bowden D W DW Meigs J B JB
Diabetologia 20120816 11
<h4>Aims/hypothesis</h4>Hyperglycaemia disproportionately affects African-Americans (AfAs). We tested the transferability of 18 single-nucleotide polymorphisms (SNPs) associated with glycaemic traits identified in European ancestry (EuA) populations in 5,984 non-diabetic AfAs.<h4>Methods</h4>We meta-analysed SNP associations with fasting glucose (FG) or insulin (FI) in AfAs from five cohorts in the Candidate Gene Association Resource. We: (1) calculated allele frequency differences, variations i ...[more]