Posttranscriptional control of T cell effector function by aerobic glycolysis.
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ABSTRACT:
SUBMITTER: Chang CH
PROVIDER: S-EPMC3804311 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Posttranscriptional control of T cell effector function by aerobic glycolysis.
Chang Chih-Hao CH Curtis Jonathan D JD Maggi Leonard B LB Faubert Brandon B Villarino Alejandro V AV O'Sullivan David D Huang Stanley Ching-Cheng SC van der Windt Gerritje J W GJ Blagih Julianna J Qiu Jing J Weber Jason D JD Pearce Edward J EJ Jones Russell G RG Pearce Erika L EL
Cell 20130601 6
A "switch" from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T cell activation and is thought to be required to meet the metabolic demands of proliferation. However, why proliferating cells adopt this less efficient metabolism, especially in an oxygen-replete environment, remains incompletely understood. We show here that aerobic glycolysis is specifically required for effector function in T cells but that this pathway is not necessary for proliferation or survival. ...[more]
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