Ontology highlight
ABSTRACT:
SUBMITTER: Rival C
PROVIDER: S-EPMC3804911 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20130819 6
NK cells are critical in immune responses against pathogens. However, their role in autoimmunity is still controversial. In this study, we demonstrate that neonatal NK cells render newborns more susceptible to neonatal autoimmunity induced by maternal autoantibodies (neonatal autoimmune ovarian disease); thus, neonatal but not adult NK cells are pathogenic after transfer into NK cell-deficient pups. The inhibitory receptors Ly49C/I are expressed in ∼5% of neonatal and ∼50% of adult NK cells. In ...[more]