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Cutting edge: antibody-dependent memory-like NK cells distinguished by FcR? deficiency.


ABSTRACT: Because NK cells lack gene-recombination machinery and are thought to be relatively short-lived, it is unclear whether NK cells can mount long-term effective recall responses to reinfections by diverse pathogens. In this article, we report that FcR?-deficient NK cells, which we recently identified and termed g(-)NK cells, possess distinct memory features directed by FcR-mediated Ab-dependent target recognition. The presence of g(-)NK cells was associated with prior human CMV (HMCV) infection, yet g(-)NK cell responses were not restricted to HCMV-infected target cells. In the presence of virus-specific Abs, g(-)NK cells had greatly enhanced functional capabilities, superior to conventional NK cells, and were highly responsive to cells infected with either HCMV or HSV-1. Remarkably, the g(-)NK cell subset persisted long-term at nearly constant levels in healthy individuals. Therefore, FcR? deficiency distinguishes an Ab-dependent memory-like NK cell subset with enhanced potential for broad antiviral responses.

SUBMITTER: Zhang T 

PROVIDER: S-EPMC3623944 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Cutting edge: antibody-dependent memory-like NK cells distinguished by FcRγ deficiency.

Zhang Tianxiang T   Scott Jeannine M JM   Hwang Ilwoong I   Kim Sungjin S  

Journal of immunology (Baltimore, Md. : 1950) 20130123 4


Because NK cells lack gene-recombination machinery and are thought to be relatively short-lived, it is unclear whether NK cells can mount long-term effective recall responses to reinfections by diverse pathogens. In this article, we report that FcRγ-deficient NK cells, which we recently identified and termed g(-)NK cells, possess distinct memory features directed by FcR-mediated Ab-dependent target recognition. The presence of g(-)NK cells was associated with prior human CMV (HMCV) infection, ye  ...[more]

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