Ontology highlight
ABSTRACT:
SUBMITTER: Bohn MF
PROVIDER: S-EPMC3805256 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Bohn Markus-Frederik MF Shandilya Shivender M D SM Albin John S JS Kouno Takahide T Anderson Brett D BD McDougle Rebecca M RM Carpenter Michael A MA Rathore Anurag A Evans Leah L Davis Ahkillah N AN Zhang Jingying J Lu Yongjian Y Somasundaran Mohan M Matsuo Hiroshi H Harris Reuben S RS Schiffer Celia A CA
Structure (London, England : 1993) 20130516 6
Human APOBEC3F is an antiretroviral single-strand DNA cytosine deaminase, susceptible to degradation by the HIV-1 protein Vif. In this study the crystal structure of the HIV Vif binding, catalytically active, C-terminal domain of APOBEC3F (A3F-CTD) was determined. The A3F-CTD shares structural motifs with portions of APOBEC3G-CTD, APOBEC3C, and APOBEC2. Residues identified to be critical for Vif-dependent degradation of APOBEC3F all fit within a predominantly negatively charged contiguous region ...[more]