Ontology highlight
ABSTRACT:
SUBMITTER: Siu KK
PROVIDER: S-EPMC4956467 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Siu Karen K KK Sultana Azmiri A Azimi Farshad C FC Lee Jeffrey E JE
Nature communications 20130101
The human APOBEC3 family of DNA cytosine deaminases serves as a front-line intrinsic immune response to inhibit the replication of diverse retroviruses. APOBEC3F and APOBEC3G are the most potent factors against HIV-1. As a countermeasure, HIV-1 viral infectivity factor (Vif) targets APOBEC3s for proteasomal degradation. Here we report the crystal structure of the Vif-binding domain in APOBEC3F and a novel assay to assess Vif-APOBEC3 binding. Our results point to an amphipathic surface that is co ...[more]