Ontology highlight
ABSTRACT:
SUBMITTER: Wong W
PROVIDER: S-EPMC3805271 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Wong W W DeVito J J Nguyen H H Sarracino D D Porcheray F F Dargon I I Pelle P D PD Collins A B AB Tolkoff-Rubin N N Smith R N RN Colvin R R Zorn E E
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20101101 11
Chronic humoral rejection (CHR) is an important cause of late graft failures following kidney transplantation. Overall, the pathophysiology of CHR is poorly understood. Matrix metalloproteinase-2 (MMP-2), a type IV collagenase, has been implicated in chronic kidney disease and allograft rejection in previous studies. We examined the presence of MMP-2 in allograft biopsies and in the urine of kidney transplant recipients with CHR. MMP-2 staining was detected by immunohistochemistry in podocytes f ...[more]