Impact of local versus global ligand density on cellular adhesion.
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ABSTRACT:
SUBMITTER: Deeg JA
PROVIDER: S-EPMC3806292 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Impact of local versus global ligand density on cellular adhesion.
Deeg Janosch A JA Louban Ilia I Aydin Daniel D Selhuber-Unkel Christine C Kessler Horst H Spatz Joachim P JP
Nano letters 20110322 4
α(v)β(3) integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to investigate cellular adhesion. The development of stable focal adhesions, their number, and size as well as the cellular adhesion strength proved to be influenced by local more than global ligand d ...[more]
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