Ontology highlight
ABSTRACT:
SUBMITTER: Han X
PROVIDER: S-EPMC8027200 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Han Xusi X Terashi Genki G Christoffer Charles C Chen Siyang S Kihara Daisuke D
Nature communications 20210407 1
An increasing number of density maps of biological macromolecules have been determined by cryo-electron microscopy (cryo-EM) and stored in the public database, EMDB. To interpret the structural information contained in EM density maps, alignment of maps is an essential step for structure modeling, comparison of maps, and for database search. Here, we developed VESPER, which captures the similarity of underlying molecular structures embedded in density maps by taking local gradient directions int ...[more]