Ontology highlight
ABSTRACT:
SUBMITTER: Defronzo RA
PROVIDER: S-EPMC3806596 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Defronzo Ralph A RA Tripathy Devjit D Schwenke Dawn C DC Banerji Maryann M Bray George A GA Buchanan Thomas A TA Clement Stephen C SC Gastaldelli Amalia A Henry Robert R RR Kitabchi Abbas E AE Mudaliar Sunder S Ratner Robert E RE Stentz Frankie B FB Musi Nicolas N Reaven Peter D PD
Diabetes 20130717 11
We examined the metabolic characteristics that attend the development of type 2 diabetes (T2DM) in 441 impaired glucose tolerance (IGT) subjects who participated in the ACT NOW Study and had complete end-of-study metabolic measurements. Subjects were randomized to receive pioglitazone (PGZ; 45 mg/day) or placebo and were observed for a median of 2.4 years. Indices of insulin sensitivity (Matsuda index [MI]), insulin secretion (IS)/insulin resistance (IR; ΔI0-120/ΔG0-120, ΔIS rate [ISR]0-120/ΔG0- ...[more]