Structure homology and interaction redundancy for discovering virus-host protein interactions.
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ABSTRACT:
SUBMITTER: de Chassey B
PROVIDER: S-EPMC3807215 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Structure homology and interaction redundancy for discovering virus-host protein interactions.
de Chassey Benoît B Meyniel-Schicklin Laurène L Aublin-Gex Anne A Navratil Vincent V Chantier Thibaut T André Patrice P Lotteau Vincent V
EMBO reports 20130906 10
Virus-host interactomes are instrumental to understand global perturbations of cellular functions induced by infection and discover new therapies. The construction of such interactomes is, however, technically challenging and time consuming. Here we describe an original method for the prediction of high-confidence interactions between viral and human proteins through a combination of structure and high-quality interactome data. Validation was performed for the NS1 protein of the influenza virus, ...[more]
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