Ontology highlight
ABSTRACT:
SUBMITTER: Blanchard C
PROVIDER: S-EPMC3807813 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Blanchard Carine C Stucke Emily M EM Burwinkel Karen K Caldwell Julie M JM Collins Margaret H MH Ahrens Annette A Buckmeier Bridget K BK Jameson Sean C SC Greenberg Allison A Kaul Ajay A Franciosi James P JP Kushner Jonathan P JP Martin Lisa J LJ Putnam Philip E PE Abonia J Pablo JP Wells Suzanne I SI Rothenberg Marc E ME
Journal of immunology (Baltimore, Md. : 1950) 20100305 7
We have previously proposed that the pathogenesis of eosinophilic esophagitis (EE) is mediated by an IL-13-driven epithelial cell response associated with marked gene dysregulation including eotaxin-3 overproduction. In this study, we compared epithelial responses between healthy patients and those with EE, aiming to uncover molecular explanations for EE pathogenesis. Esophageal epithelial cells could be maintained for up to five passages, with 67% and 62% of cell lines reaching confluence in he ...[more]