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Homologous recombination in E3 genes of human adenovirus species D.

ABSTRACT: Genes within the E3 transcription unit of human adenoviruses modulate host immune responses to infection. A comprehensive genomics and bioinformatics analysis of the E3 transcription unit for 38 viruses within human adenovirus species D (HAdV-D) revealed distinct and surprising patterns of homologous recombination. Homologous recombination was identified in open reading frames for E3 CR1?, CR1?, and CR1?, similar to that previously observed with genes encoding the three major structural capsid proteins, the penton base, hexon, and fiber.

SUBMITTER: Singh G

PROVIDER: S-EPMC3807923 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Homologous recombination in E3 genes of human adenovirus species D.

Singh Gurdeep G Robinson Christopher M CM Dehghan Shoaleh S Jones Morris S MS Dyer David W DW Seto Donald D Chodosh James J

Journal of virology 20130911 22

Genes within the E3 transcription unit of human adenoviruses modulate host immune responses to infection. A comprehensive genomics and bioinformatics analysis of the E3 transcription unit for 38 viruses within human adenovirus species D (HAdV-D) revealed distinct and surprising patterns of homologous recombination. Homologous recombination was identified in open reading frames for E3 CR1α, CR1β, and CR1γ, similar to that previously observed with genes encoding the three major structural capsid p ...[more]

PMID: 24027303

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