Ontology highlight
ABSTRACT:
SUBMITTER: Fallon SJ
PROVIDER: S-EPMC3808120 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Fallon S J SJ Hampshire A A Williams-Gray C H CH Barker R A RA Owen A M AM
Neuropsychologia 20130801 11
Planning, the decomposition of an ultimate goal into a number of sub-goals is critically dependent upon fronto-striatal dopamine (DA) levels. Here, we examined the extent to which the val158met polymorphism in the catechol O-methyltransferase (COMT) gene, which is thought to primarily alter cortical DA levels, affects performance and fronto-parietal activity during a planning task (Tower of London). COMT genotype was found to modulate activity in the left superior posterior parietal cortex (SPC) ...[more]