Ontology highlight
ABSTRACT:
SUBMITTER: Duvarci S
PROVIDER: S-EPMC6053467 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Nature communications 20180719 1
The dopamine (DA) system plays a major role in cognitive functions through its interactions with several brain regions including the prefrontal cortex (PFC). Conversely, disturbances in the DA system contribute to cognitive deficits in psychiatric diseases, yet exactly how they do so remains poorly understood. Here we show, using mice with disease-relevant alterations in DA signaling (D2R-OE mice), that deficits in working memory (WM) are associated with impairments in the WM-dependent firing pa ...[more]