Ontology highlight
ABSTRACT:
SUBMITTER: Ahlstrom LS
PROVIDER: S-EPMC3808462 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Ahlstrom Logan S LS Dickson Alex A Brooks Charles L CL
The journal of physical chemistry. B 20130701 42
The small pH stress-sensing chaperone HdeA helps pathogenic enteric E. coli survive passage through the severely acidic environment of the mammalian stomach. Under stress conditions, HdeA transitions from an inactive folded dimer to a chaperone-active unfolded monomer to prevent the acid-induced aggregation of periplasmic proteins. Here we use a topology-based Gō-like model to delineate the relationship between dimer interface formation and monomer folding and to better understand the structural ...[more]