Ontology highlight
ABSTRACT:
SUBMITTER: Behnen P
PROVIDER: S-EPMC6147235 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Behnen Petra P Felline Angelo A Comitato Antonella A Di Salvo Maria Teresa MT Raimondi Francesco F Gulati Sahil S Kahremany Shirin S Palczewski Krzysztof K Marigo Valeria V Fanelli Francesca F
iScience 20180505
The autosomal dominant form of retinitis pigmentosa (adRP) is a blindness-causing conformational disease largely linked to mutations of rhodopsin. Molecular simulations coupled to the graph-based protein structure network (PSN) analysis and in vitro experiments were conducted to determine the effects of 33 adRP rhodopsin mutations on the structure and routing of the opsin protein. The integration of atomic and subcellular levels of analysis was accomplished by the linear correlation between indi ...[more]