Ontology highlight
ABSTRACT:
SUBMITTER: Ito I
PROVIDER: S-EPMC3809783 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Ito Ichiaki I Waku Tsuyoshi T Aoki Masato M Abe Rumi R Nagai Yu Y Watanabe Tatsuya T Nakajima Yuka Y Ohkido Ichiro I Yokoyama Keitaro K Miyachi Hiroyuki H Shimizu Toshiyuki T Murayama Akiko A Kishimoto Hiroyuki H Nagasawa Kazuo K Yanagisawa Junn J
The Journal of clinical investigation 20131025 11
The TGF-β superfamily comprises pleiotropic cytokines that regulate SMAD and non-SMAD signaling. TGF-β-SMAD signal transduction is known to be involved in tissue fibrosis, including renal fibrosis. Here, we found that 1,25-dihydroxyvitamin D3-bound [1,25(OH)2D3-bound] vitamin D receptor (VDR) specifically inhibits TGF-β-SMAD signal transduction through direct interaction with SMAD3. In mouse models of tissue fibrosis, 1,25(OH)2D3 treatment prevented renal fibrosis through the suppression of TGF- ...[more]