DNA methylation in repetitive elements and post-traumatic stress disorder: a case-control study of US military service members.
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ABSTRACT:
SUBMITTER: Rusiecki JA
PROVIDER: S-EPMC3809831 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
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DNA methylation in repetitive elements and post-traumatic stress disorder: a case-control study of US military service members.
Rusiecki Jennifer A JA Chen Ligong L Srikantan Vasantha V Zhang Lei L Yan Liying L Polin Matthew L ML Baccarelli Andrea A
Epigenomics 20120201 1
<h4>Aim</h4>We investigated serum DNA methylation patterns in genomic repetitive elements, LINE-1 and Alu, for post-traumatic stress disorder (PTSD) cases and controls who were US military service members recently deployed to Afghanistan or Iraq.<h4>Methods</h4>Cases (n = 75) had a postdeployment diagnosis of PTSD. Controls (n = 75) were randomly selected service members with no postdeployment PTSD diagnosis. Pre- and post-deployment sera were accessed, DNA was extracted and DNA methylation (per ...[more]
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