Dataset Information

Cyclooxygenase-2 polymorphisms and susceptibility to colorectal cancer: a meta-analysis.

ABSTRACT: PURPOSE: Four polymorphisms, -765G>C, -1195G>A, 8473T>C, and Val511Ala, in the cyclooxygenase-2 (COX-2) gene were identified to be associated with colorectal cancer (CRC) risk. However, the results are inconsistent. The objective of this meta-analysis was to evaluate the association between these four polymorphisms and the risk of CRC. MATERIALS AND METHODS: All eligible case-control studies published up to December 2012 on the association between the four polymorphisms of COX-2 and CRC risk were identified by searching PubMed and Web of Science. The CRC risk associated with the four polymorphisms of the COX-2 gene was estimated for each study by odds ratio (OR) together with its 95% confidence interval (CI), respectively. RESULTS: A total of 15 case-control studies were included. Overall, no evidence has indicated that the -1195A allele, -765C allele, 8473C allele, and 511Ala allele are associated with susceptibility to CRC (-1195G>A: OR=1.11, 95% CI: 0.82-1.51, p=0.78; -765G>C: OR=1.08, 95% CI: 0.96-1.21, p=0.07; 8473T>C: OR=1.03, 95% CI: 0.89-1.18, p=0.91; Val511Ala: OR=0.71, 95% CI: 0.46-1.09, p=0.94). However, stratified analysis with ethnicity indicated that individuals with -765GC or GC/CC genotypes had an increased risk of CRC among Asian populations (GC vs. GG: OR=1.05, 95% CI: 0.87-1.28, p=0.03; GC+CC vs. GG: OR=1.08, 95% CI: 0.96-1.21, p=0.07). CONCLUSION: This meta-analysis indicated that -765G>C polymorphism was significantly associated with susceptibility to CRC in Asian populations.

SUBMITTER: Wang J

PROVIDER: S-EPMC3809860 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Cyclooxygenase-2 polymorphisms and susceptibility to colorectal cancer: a meta-analysis.

Wang Jun J Guo Xufeng X Zhang Jixiang J Song Jia J Ji Mengyao M Yu Shijie S Wang Jing J Cao Zhuo Z Dong Weiguo W

Yonsei medical journal 20131101 6

<h4>Purpose</h4>Four polymorphisms, -765G>C, -1195G>A, 8473T>C, and Val511Ala, in the cyclooxygenase-2 (COX-2) gene were identified to be associated with colorectal cancer (CRC) risk. However, the results are inconsistent. The objective of this meta-analysis was to evaluate the association between these four polymorphisms and the risk of CRC.<h4>Materials and methods</h4>All eligible case-control studies published up to December 2012 on the association between the four polymorphisms of COX-2 and ...[more]

PMID: 24142638

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Project description:BackgroundStudies investigating the association between single-nucleotide polymorphisms (SNPs) of the cytochrome P450 1B1 (CYP1B1) and prostate cancer (PCa) risk report conflicting results. To derive a more precise estimation of the relationship between CYP1B1 polymorphisms and PCa risk, a meta-analysis was performed.Methodology/principal findingsA comprehensive literature search was conducted to identify all eligible studies of CYP1B1 polymorphisms and PCa risk. A total of 14 independent studies, including 6380 cases and 5807 controls, were identified. We investigated by meta-analysis the effects of 5 polymorphisms in CYP1B1 L432V (12 studies, 5999 cases, 5438 controls), R48G (6 studies, 1647 cases, 1846 controls), N453S (4 studies, 1407 cases, 1499 controls), -13C/T (4 studies, 1116 cases, 1114 controls), and A119S (4 studies, 1057 cases, 1018 controls). There was no evidence that L432V had significant association with PCa in overall population. After subgroup analyses by ethnicity, we found that L432V was significantly associated with PCa risk in Asians (additive: OR?=?2.38, 95%CI?=?1.31-4.33, P?=?0.004; recessive: OR?=?2.11, 95%CI?=?1.17-3.79, P?=?0.01; dominant: OR?=?1.52, 95%CI?=?1.14-2.01, P?=?0.004; allelic: OR?=?1.52, 95%CI?=?1.20-1.92, P?=?0.0006). When stratified by source of controls, significantly elevated PCa risk was found in all genetic models in population based studies (additive: OR?=?1.34, 95%CI?=?1.14-1.57, P?=?0.0003; recessive: OR?=?1.25, 95%CI?=?1.09-1.43, P?=?0.002; dominant: OR?=?1.25, 95%CI?=?1.11-1.41, P?=?0.0002; allelic: OR?=?1.18, 95%CI?=?1.09-1.28, P<0.0001). For N453S, there was a significant association between N453S polymorphism and PCa risk in both overall population (dominant: OR?=?1.18, 95%CI?=?1.00-1.38, P?=?0.04) and mixed population (domiant: OR?=?1.31, 95%CI?=?1.06-1.63, P?=?0.01; allelic: OR?=?1.27, 95%CI?=?1.05-1.54, P?=?0.01). For A119S, our analysis suggested that A119S was associated with PCa risk under recessive model in overall population (OR?=?1.37, 95%CI?=?1.04-1.80, P?=?0.03).ConclusionsThe results suggest that L432V, N453S, and A119S polymorphisms of CYP1B1 might be associated with the susceptibility of PCa. Further larger and well-designed multicenter studies are warranted to validate these findings.

Dataset Information

Cyclooxygenase-2 polymorphisms and susceptibility to colorectal cancer: a meta-analysis.

Publications

Cyclooxygenase-2 polymorphisms and susceptibility to colorectal cancer: a meta-analysis.

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