Ontology highlight
ABSTRACT:
SUBMITTER: Panagopoulos I
PROVIDER: S-EPMC3810351 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Panagopoulos Ioannis I Gorunova Ludmila L Brandal Petter P Garnes Margaret M Tierens Anne A Heim Sverre S
Oncology reports 20130718 4
The rare but recurrent RUNX1-USP42 fusion gene is the result of a t(7;21)(p22;q22) chromosomal translocation and has been described in 6 cases of acute myeloid leukemia (AML) and one case of refractory anemia with excess of blast. In the present study, we present the molecular genetic analysis and the clinical features of a t(7;21)(p22;q22)-positive AML case. PCR amplified two RUNX1-USP42 cDNA fragments but no reciprocal USP42-RUNX1 fragment indicating that the RUNX1-USP42 is the leukemogenic fu ...[more]