Ontology highlight
ABSTRACT:
SUBMITTER: Torkildsen S
PROVIDER: S-EPMC4505893 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Torkildsen Synne S Gorunova Ludmila L Beiske Klaus K Tjønnfjord Geir E GE Heim Sverre S Panagopoulos Ioannis I
PloS one 20150717 7
RNA-sequencing of a case of acute myeloid leukemia with the bone marrow karyotype 46,XY,t(2;14)(q22;q32)[5]/47,XY,idem,+?4,del(6)(q13q21)[cp6]/46,XY[4] showed that the t(2;14) generated a ZEB2-BCL11B chimera in which exon 2 of ZEB2 (nucleotide 595 in the sequence with accession number NM_014795.3) was fused to exon 2 of BCL11B (nucleotide 554 in the sequence with accession number NM_022898.2). RT-PCR together with Sanger sequencing verified the presence of the above-mentioned fusion transcript. ...[more]