Ontology highlight
ABSTRACT:
SUBMITTER: Sompallae R
PROVIDER: S-EPMC3810939 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sompallae Ramakrishna R Hofmann Oliver O Maher Christopher A CA Gedye Craig C Behren Andreas A Vitezic Morana M Daub Carsten O CO Devalle Sylvie S Caballero Otavia L OL Carninci Piero P Hayashizaki Yoshihide Y Lawlor Elizabeth R ER Cebon Jonathan J Hide Winston W
Frontiers in genetics 20131029
PROM1 is the gene encoding prominin-1 or CD133, an important cell surface marker for the isolation of both normal and cancer stem cells. PROM1 transcripts initiate at a range of transcription start sites (TSS) associated with distinct tissue and cancer expression profiles. Using high resolution Cap Analysis of Gene Expression (CAGE) sequencing we characterize TSS utilization across a broad range of normal and developmental tissues. We identify a novel proximal promoter (P6) within CD133(+) melan ...[more]