Ontology highlight
ABSTRACT:
SUBMITTER: Tian L
PROVIDER: S-EPMC6626869 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Tian Lu L Truong Marie-José MJ Lagadec Chann C Adriaenssens Eric E Bouchaert Emmanuel E Bauderlique-Le Roy Hélène H Figeac Martin M Le Bourhis Xuefen X Bourette Roland P RP
Stem cell reports 20190613 1
During normal mammary gland development, s-SHIP promoter expression marks a distinct type of mammary stem cells, at two different stages, puberty and early mid-pregnancy. To determine whether s-SHIP is a marker of mammary cancer stem cells (CSCs), we generated bitransgenic mice by crossing the C3(1)-SV40 T-antigen transgenic mouse model of breast cancer, and a transgenic mouse (11.5kb-GFP) expressing green fluorescent protein from the s-SHIP promoter. Here we show that in mammary tumors originat ...[more]