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Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis.

ABSTRACT: Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis. Draft genome sequencing revealed a gene (the tvaA gene) encoding the thioviridamide precursor peptide. The thioviridamide biosynthesis gene cluster was identified by heterologous production of thioviridamide in Streptomyces lividans.

SUBMITTER: Izawa M

PROVIDER: S-EPMC3811549 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis.

Izawa Masumi M Kawasaki Takashi T Hayakawa Yoichi Y

Applied and environmental microbiology 20130830 22

Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis. Draft genome sequencing revealed a gene (the tvaA gene) encoding the thioviridamide precursor peptide. The thioviridamide biosynthesis gene cluster was identified by heterologous production of thioviridamide in Streptomyces lividans. ...[more]

PMID: 23995943

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