Ontology highlight
ABSTRACT:
SUBMITTER: Castro JF
PROVIDER: S-EPMC4551226 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Castro Jean Franco JF Razmilic Valeria V Gomez-Escribano Juan Pablo JP Andrews Barbara B Asenjo Juan A JA Bibb Mervyn J MJ
Applied and environmental microbiology 20150619 17
Streptomyces leeuwenhoekii, isolated from the hyperarid Atacama Desert, produces the new ansamycin-like compounds chaxamycins A to D, which possess potent antibacterial activity and moderate antiproliferative activity. We report the development of genetic tools to manipulate S. leeuwenhoekii and the identification and partial characterization of the 80.2-kb chaxamycin biosynthesis gene cluster, which was achieved by both mutational analysis in the natural producer and heterologous expression in ...[more]