Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC3812298 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Wang Changning C Wilson Colin M CM Moseley Christian K CK Carlin Stephen M SM Hsu Shirley S Arabasz Grae G Schroeder Frederick A FA Sander Christin Y CY Hooker Jacob M JM
Nuclear medicine and biology 20130815 8
A wide range of central nervous system (CNS) disorders, particularly those related to sleep, are associated with the abnormal function of orexin (OX) receptors. Several orexin receptor antagonists have been reported in recent years, but currently there are no imaging tools to probe the density and function of orexin receptors in vivo. To date there are no published data on the pharmacokinetics (PK) and accumulation of some lead orexin receptor antagonists. Evaluation of CNS pharmacokinetics in t ...[more]