Ontology highlight
ABSTRACT:
SUBMITTER: Bernard JJ
PROVIDER: S-EPMC3812946 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Bernard Jamie J JJ Cowing-Zitron Christopher C Nakatsuji Teruaki T Muehleisen Beda B Muto Jun J Borkowski Andrew W AW Martinez Laisel L Greidinger Eric L EL Yu Benjamin D BD Yu Benjamin D BD Gallo Richard L RL
Nature medicine 20120708 8
Exposure to ultraviolet B (UVB) radiation from the sun can result in sunburn, premature aging and carcinogenesis, but the mechanism responsible for acute inflammation of the skin is not well understood. Here we show that RNA is released from keratinocytes after UVB exposure and that this stimulates production of the inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) from nonirradiated keratinocytes and peripheral blood mononuclear cells (PBMCs). Whole-transcriptome s ...[more]