Ontology highlight
ABSTRACT:
SUBMITTER: Zeng X
PROVIDER: S-EPMC3813441 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Zeng Xue X Chen Haoyan H Gupta Rashmi R Paz-Altschul Oscar O Bowcock Anne M AM Liao Wilson W
Experimental dermatology 20131001 10
Psoriasis is an inflammatory, immune-mediated disease of the skin. Several studies have suggested that natural killer (NK) cells and their receptors may be important for its pathogenesis. Here, we examined whether deletion of the activating natural killer receptor gene NKG2C, which has a frequency of 20% in the European population, was associated with psoriasis susceptibility. The NKG2C deletion and a functional polymorphism in its ligand HLA-E were genotyped in a Caucasian cohort of 611 psorias ...[more]