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?-AApeptides bind to RNA by mimicking RNA-binding proteins.

ABSTRACT: The interactions between proteins and RNAs are of vital importance for many cellular processes, including transcription and processing of RNA, translation, and viral infections. Here we report an ?-AApeptide that can mimic HIV-1 Tat protein and bind to TAR RNAs of HIV and BIV with nanomolar affinity, comparable to that of the RNA-binding fragment of Tat (amino acids 49-58). The interaction is resistant to the presence of a large excess of tRNA. With resistance to proteolytic hydrolysis and limitless potential for diversification, ?-AApeptides may emerge as a new class of peptidomimetics to modulate RNA-protein interactions.

SUBMITTER: Niu Y

PROVIDER: S-EPMC3814216 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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γ-AApeptides bind to RNA by mimicking RNA-binding proteins.

Niu Youhong Y Jones Alisha Jonesy AJ Wu Haifan H Varani Gabriele G Cai Jianfeng J

Organic & biomolecular chemistry 20110808 19

The interactions between proteins and RNAs are of vital importance for many cellular processes, including transcription and processing of RNA, translation, and viral infections. Here we report an γ-AApeptide that can mimic HIV-1 Tat protein and bind to TAR RNAs of HIV and BIV with nanomolar affinity, comparable to that of the RNA-binding fragment of Tat (amino acids 49-58). The interaction is resistant to the presence of a large excess of tRNA. With resistance to proteolytic hydrolysis and limit ...[more]

PMID: 21826330

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