Ontology highlight
ABSTRACT:
SUBMITTER: Kassner I
PROVIDER: S-EPMC3814718 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Kassner Ingrid I Andersson Anneli A Fey Monika M Tomas Martin M Ferrando-May Elisa E Hottiger Michael O MO
Open biology 20131002 10
ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1, formerly PARP1) is localized in the nucleus, where it ADP-ribosylates specific target proteins. The post-translational modification (PTM) with a single ADP-ribose unit or with polymeric ADP-ribose (PAR) chains regulates protein function as well as protein-protein interactions and is implicated in many biological processes and diseases. SET7/9 (Setd7, KMT7) is a protein methyltransferase that catalyses lysine monomethylation of histones, but ...[more]