New design of helix bundle peptide-polymer conjugates.
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ABSTRACT:
SUBMITTER: Shu JY
PROVIDER: S-EPMC3815612 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
New design of helix bundle peptide-polymer conjugates.
Shu Jessica Y JY Tan Cen C DeGrado William F WF Xu Ting T
Biomacromolecules 20080716 8
We present a new design of peptide-polymer conjugates where a polymer chain is covalently linked to the side chain of a helix bundle-forming peptide. The effect of conjugated polymer chains on the peptide structure was examined using a de novo designed three-helix bundle and a photoactive four-helix bundle. Upon attachment of poly(ethylene glycol) to the exterior of the coiled-coil helix bundle, the peptide secondary structure was stabilized and the tertiary structure, that is, the coiled-coil h ...[more]
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